Stem cell regenerative therapy is a growing treatment option for many conditions. Greater knowledge of the biology of stem cells has provided new insights and opportunity for clinical applications.

Bone marrow aspirate (BMA) is becoming more widely used in regenerative medicine because it is known to harbor stem cells with the potential to repair damaged tissues. Modern technology allows us to concentrate the stem cells, and isolate them from other cells within bone marrow, in order to gain the maximum potential of BMA. In theory, delivery of concentrated BMA (cBMA) to the desired site will generate new tissue growth. cBMA has been used as an adjunct in bone and soft tissue healing throughout the body. cBMA contains all of the growth factors and healing components in PRP, along with concentrated progenitor, or stem-like, cells which further enhance the regenerative process. Research and our experience shows that there are some applications where a combination of stem cells and platelets (PRP) may be the best treatment option.

The process of concentrating BMA to harness its regenerative properties has recently become more widely accepted and utilized in orthopedics, with applications ranging from non-surgical treatment of degenerative joints and cartilage lesions to non-invasive treatment of nonunions and open surgical applications, where cBMA is used independently at closure or combined with other carriers, such as synthetic bone graft substitutes, in an attempt to create an ideal environment for healing and regeneration in the host tissue.

Stem cells are progenitor cells which can become a wide variety of specialized cell types due to their differentiation capacity. Once injected or applied, stem cells identify the damaged tissues and aid in their repair and regeneration.
An experienced physician harvests the BMA from the iliac crest, proximal tibia or calcaneus using a bone marrow aspiration needle.

Once the BMA is harvested, it is concentrated in a special device. The concentrate may be used to produce both an injectable product and a topical product to assist in regenerative therapy. cBMA can be mixed with other (off the shelf) stem-cell based products (bone graft substitutes, skin graft substitutes) in surgical applications. cBMA can be injected (non-surgically or post-operatively) to non-union sites, intra-articularly (in joint space), or to sites of cartilage or soft-tissue defects to encourage regeneration.